| Assignment | Title/Topic question |
| PICO 1 | In adults with grade II-IV hemorrhoidal disease, how does a transanal hemorrhoidal dearterlization compare to hemorrhoidectomy in terms of post operative outcomes (pain, complications, recurrence, and patient satisfaction)? |
| PICO 2 | In adults with simple anal fistula, does fistulotomy compared with seton placement result in higher rates of fistula healing and lower recurrence without increasing the risk of fecal incontinence? |
| PICO 3 | In adults undergoing cholecystectomy for cholecystitis, does robotic cholecystectomy compared with laparoscopic cholecystectomy result in lower rates of intraoperative complications and conversion to open surgery while maintaining similar operative time and length of hospital stay? |
| PICO 4 | In adults with primary hypertension, does treatment with angiotensin-converting enzyme (ACE) inhibitors compared with angiotensin receptor blockers (ARBs) result in greater reductions in systolic and diastolic blood pressure while maintaining similar rates of adverse effects and medication adherence? |
| PICO 5 | In adults with type 2 diabetes and established atherosclerotic cardiovascular disease, does treatment with GLP-1 receptor agonists (e.g., semaglutide) compared with SGLT2 inhibitors (e.g., empagliflozin) result in a greater reduction of major adverse cardiovascular events (MACE) while maintaining a similar risk profile for acute kidney injury and treatment discontinuation? |
| PICO 6 | In adults with primary hyperlipidemia and a high 10-year risk of atherosclerotic cardiovascular disease (ASCVD), does treatment with high-intensity statins (e.g., atorvastatin 80 mg) compared with moderate-intensity statins (e.g., simvastatin 40 mg) result in a greater reduction of major adverse cardiovascular events (MACE) while maintaining a similar safety profile regarding the incidence of new-onset diabetes mellitus and statin-associated muscle symptoms (SAMS)? |
| Draft Mini-CAT | In adult patients suspected of having DVT, how does the diagnostic accuracy of point-of-care ultrasound performed by a clinician compare to a formal radiology-performed duplex ultrasound? |
| Final Mini-CAT | In adult patients suspected of having DVT, how does the diagnostic accuracy of point-of-care ultrasound performed by a clinician compare to a formal radiology-performed duplex ultrasound? |
